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Î2-HS glycoprotein (A2HS) is a glycoprotein (molecular weight 49 000) present in human plasma at levels ranging between 40 and 85 mg/dl. A2HS is a major protein component of the bone matrix and could be involved both in mineralization and bone resorption.
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Thrombin is an endolytic serine protease that selectively cleaves the Arg-Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.1 2The optimal cleavage sites for thrombin are as follows1. A-B-Pro-Arg--X-Y where A and B are hydrophobic amino acids and X and Y are nonacidic amino acids.2. Gly-Arg--GlyRecombinant human thrombin protease is expressed in human HEK 293 cells as a glycoprotein heterodimer. The DTT-reduced protein migrates as two bands of 31 kDa (heavy chain) and 6 kDa (light chain) on SDS-PAGE. This protein is manufactured in human cells with no serum. The human cells expression system allows human-like glycosylation and folding and often supports higher activity of the protein. This thrombin protease is useful for cleaving recombinant proteins that are expressed as fusion proteins with this sequence between the carrier domain and the protein of interest.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
The MESO SCALE DISCOVERY U-PLEX Human ApoC3 Assay is an advanced immunoassay for the precise quantitative detection of human Apolipoprotein C-III (ApoC3). This assay is designed for use with various sample types and is suitable for metabolic research applications, providing high sensitivity and specificity. Key features include compatibility with multiple MSD instrument systems and minimal non-specific binding.
Precise measurement of ApoC3
High sensitivity with a lower limit of detection of 1.06 pg/mL
Wide dynamic range from 1.06 to 10,000 pg/mL
Multiple sample type compatibility including serum, plasma, and cell culture media
Supports multiplexing options
Less than 0.5% non-specific binding
Uses mouse monoclonal capture and detection antibodies
For research use only
Stored as multi-component kit
Fits with Biomarker Group 3
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A synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM) cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM); prevents the degradation of IκBα and IκBβ by the ubiquitin-proteasome complex, which blocks activation of NFκB and the production of TNF and IL-1β
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Lipoprotein lipase hydrolyzes triglycerides in plasma lipoproteins causing release of fatty acids for metabolic purposes in muscles and adipose tissue.
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